Paracetamol, also known as acetaminophen, is one of the most widely used active pharmaceutical ingredients (APIs) for its analgesic and antipyretic properties. Chemically identified as N-(4-hydroxyphenyl)acetamide, it is extensively prescribed and also available over-the-counter for managing mild to moderate pain such as headaches, muscle aches, and menstrual cramps, as well as for reducing fever. Its mechanism of action involves inhibition of prostaglandin synthesis in the brain, which helps regulate pain and temperature. Paracetamol is formulated in various dosage forms, including tablets, syrups, capsules, suspensions, and injections, making it accessible to all age groups. It provides rapid relief, typically within an hour, and is regarded as safe when used at recommended doses. However, accidental or intentional overdose can cause severe hepatotoxicity, highlighting the importance of responsible usage. Despite this risk, its affordability, high efficacy, and tolerability have made it a staple in both hospital and household medicine cabinets. With continuous innovations, paracetamol is often combined with caffeine or NSAIDs for enhanced effects and is also available in extended-release formulations. Its global demand remains consistently high, solidifying its position as one of the most essential medicines in modern healthcare.